論文
2024年
- Chika Nakagawa, Tsunekazu Oikawa, Kohji Yamada, Akihito Tsubota, Chisato Saeki, Kuniko Katagiri, Naoko Tago, Hiroshi Kamioka, Kaoru Ueda, Koichiro Haruki, et al. Protein kinase C delta enhances the diagnostic performance of hepatocellular carcinoma. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2024. 1-13
2023年
- Kohji Yamada, Yoshito Hannya, Tsunekazu Oikawa, Ayano Yoshida, Kuniko Katagiri, Saishu Yoshida, Rei Koizumi, Naoko Tago, Yuya Shimoyama, Akira Kawamura, et al. Extended-Synaptotagmin 1 Enhances Liver Cancer Progression Mediated by the Unconventional Secretion of Cytosolic Proteins. Molecules. 2023. 28. 10
- Kohji Yamada, Kiyotsugu Yoshida. Cancer-related unconventional protein secretion: a new role of the endoplasmic reticulum. DNA and Cell Biology. 2023
- Yuya Shimoyama, Kohji Yamada, Saishu Yoshida, Akira Kawamura, Yoshito Hannya, Yuta Imaizumi, Tomotaka Kumamoto, Yasuhiro Takeda, Masayuki Shimoda, Ken Eto, et al. Inhibition of protein kinase C delta leads to cellular senescence to induce anti-tumor effects in colorectal cancer. Cancer science. 2023. 114. 6. 2471-2484
- Kohji Yamada, Kiyotsugu Yoshida. Leakage? or Secretion? unconventional protein secretion in cancer. Oncotarget. 2023. 14. 1. 146-147
2022年
- Kohji Yamada, Saya Motohashi, Tsunekazu Oikawa, Naoko Tago, Rei Koizumi, Masaya Ono, Toshiaki Tachibana, Ayano Yoshida, Saishu Yoshida, Masayuki Shimoda, et al. Extended-synaptotagmin 1 engages in unconventional protein secretion mediated via SEC22B+ vesicle pathway in liver cancer. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119. 36. e2202730119
- Tsunekazu Oikawa, Kohji Yamada, Akihito Tsubota, Chisato Saeki, Naoko Tago, Chika Nakagawa, Kaoru Ueda, Hiroshi Kamioka, Tomohiko Taniai, Koichiro Haruki, et al. Protein Kinase C delta Is a Novel Biomarker for Hepatocellular Carcinoma. Gastro Hep Advances. 2022. 2. 1. 83-95
- Akira Kawamura, Saishu Yoshida, Katsuhiko Aoki, Yuya Shimoyama, Kohji Yamada, Kiyotsugu Yoshida. DYRK2 maintains genome stability via neddylation of cullins in response to DNA damage. Journal of cell science. 2022
- Kohji Yamada, Ryusuke Kizawa, Ayano Yoshida, Rei Koizumi, Saya Motohashi, Yuya Shimoyama, Yoshito Hannya, Saishu Yoshida, Tsunekazu Oikawa, Masayuki Shimoda, et al. Extracellular PKCδ signals to epidermal growth factor receptor for tumor proliferation in liver cancer cells. Cancer science. 2022. 113. 7. 2378-2385
- Kohji Yamada, Kiyotsugu Yoshida. Multiple subcellular localizations and functions of protein kinase Cδ in liver cancer. World journal of gastroenterology. 2022. 28. 2. 188-198
2021年以前
- Kohji Yamada, Tsunekazu Oikawa, Ryusuke Kizawa, Saya Motohashi, Saishu Yoshida, Tomotaka Kumamoto, Chisato Saeki, Chika Nakagawa, Yuya Shimoyama, Katsuhiko Aoki, et al. Unconventional Secretion of PKCδ Exerts Tumorigenic Function via Stimulation of ERK1/2 Signaling in Liver Cancer. Cancer research. 2021. 81. 2. 414-425
- Saishu Yoshida, Katsuhiko Aoki, Ken Fujiwara, Takashi Nakakura, Akira Kawamura, Kohji Yamada, Masaya Ono, Satomi Yogosawa, Kiyotsugu Yoshida. The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis. eLife. 2020. 9
- Tomotaka Kumamoto, Kohji Yamada, Saishu Yoshida, Katsuhiko Aoki, Shinichi Hirooka, Ken Eto, Katsuhiko Yanaga, Kiyotsugu Yoshida. Impairment of DYRK2 by DNMT1-mediated transcription augments carcinogenesis in human colorectal cancer. International journal of oncology. 2020. 56. 6. 1529-1539
- Mutsumi Hayashi, Hiroko Madokoro, Koji Yamada, Hiroko Nishida, Chikao Morimoto, Michiie Sakamoto, Hiroshi Yanagawa, Taketo Yamada. Novel Antibody-Drug Conjugate with Anti-CD26 Humanized Monoclonal Antibody and Transcription Factor IIH (TFIIH) Inhibitor, Triptolide, Inhibits Tumor Growth via Impairing mRNA Synthesis. Cancers. 2019. 11. 8
- K. Yamada, K. Yoshida. Mechanical insights into the regulation of programmed cell death by p53 via mitochondria. Biochim Biophys Acta Mol Cell Res. 2019. 18665. 5. 839-848
- Tetsuji Moriyama, Shu Tanaka, Yasumune Nakayama, Masahiro Fukumoto, Kenji Tsujimura, Kohji Yamada, Takeshi Bamba, Yoshihiro Yoneda, Eiichiro Fukusaki, Masahiro Oka. Two isoforms of TALDO1 generated by alternative translational initiation show differential nucleocytoplasmic distribution to regulate the global metabolic network. Scientific reports. 2016. 6. 34648
- Y. Miyamoto, K. Yamada, Y. Yoneda. Importin α: a key molecule in nuclear transport and non-transport functions. Journal of Biochemistry. 2016. 160. 2. 69-75
- Kohji Yamada, Yoichi Miyamoto, Akira Tsujii, Tetsuji Moriyama, Yudai Ikuno, Takashi Shiromizu, Satoshi Serada, Minoru Fujimoto, Takeshi Tomonaga, Tetsuji Naka, et al. Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling. Scientific reports. 2016. 6. 21410. 21410-21410
- Masahiro Oka, Sonoko Mura, Kohji Yamada, Percival Sangel, Saki Hirata, Kazumitsu Maehara, Koichi Kawakami, Taro Tachibana, Yasuyuki Ohkawa, Hiroshi Kimura, et al. Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes. eLIFE. 2016. 5. e09540
- Mutsumi Hayashi, Hiroko Madokoro, Koji Yamada, Hiroko Nishida, Chikao Morimoto, Michiie Sakamoto, Taketo Yamada. A humanized anti-CD26 monoclonal antibody inhibits cell growth of malignant mesothelioma via retarded G2/M cell cycle transition. Cancer cell international. 2016. 16. 35. 35-35
- L. Yang, M. Fujimoto, H. Murota, S. Serada, M. Fujimoto, H. Honda, K. Yamada, K. Suzuki, A. Nishikawa, Y. Hosono, et al. Proteomic identification of heterogeneous nuclear RNP-K as a novel cold-associated autoantigen in patients with secondary Raynaud’s phenomenon. Rheumatology. 2015. 54. 2. 349-358
- Kohji Yamada, Mutsumi Hayashi, Hiroko Madokoro, Hiroko Nishida, Wenlin Du, Kei Ohnuma, Michiie Sakamoto, Chikao Morimoto, Taketo Yamada. Nuclear localization of CD26 induced by a humanized monoclonal antibody inhibits tumor cell growth by modulating of POLR2A transcription. PloS one. 2013. 8. 4. e62304
- Kohji Yamada, Mutsumi Hayashi, Wenlin Du, Kei Ohnuma, Michiie Sakamoto, Chikao Morimoto, Taketo Yamada. Localization of CD26/DPPIV in nucleus and its nuclear translocation enhanced by anti-CD26 monoclonal antibody with anti-tumor effect. Cancer cell international. 2009. 9. 17. 17-17
- Kensuke Kondoh, Yuji Nakata, Takashi Yamaoka, Mitsuo Itakura, Mutsumi Hayashi, Kohji Yamada, Jun-ichi Hata, Taketo Yamada. Altered cellular immunity in transgenic mice with T cell-specific expression of human D4-guanine diphosphate-dissociation inhibitor (D4-GDI). International immunology. 2008. 20. 10. 1299-1311
プレスリリース
ペルセウス通信 2024年3月 インターネットメディア
時事メディカル 2023年10月 インターネットメディア
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化学工業日報 朝刊6面 2020年12月 新聞・雑誌